온라인강의

Bidirectional regulation in drug addiction by acupuncture
강사명Chaeha Yang 강의시간25분 강의개설일2025-12-09
온라인강의

강의소개

Drug craving is one of the major challenges in the treatment of drug addiction, which has been proposed as a critical contributor to relapse. There is lot of interest in gaining a better understanding of how acupuncture works in the brain to modulate drug craving. Neurochemical and behavioral evidence has shown the neurobiological mechanisms underlying acupuncture’s effectiveness in the treatment of drug addiction, on the basis of two different theories (the incentive sensitization theory and the opponent process theory) that have seemingly opposite views on the role of the mesolimbic dopamine pathway in mediating relapse to drug-seeking behavior. Results provide evidence that acupuncture normalizes hyper-reactivity or hypoactivity of the mesolimbic dopamine system in these opposed processes involved in drug addiction by regulating several brain neurotransmitters such as GABA and opioid. This suggests that acupuncture may reduce drug craving by correcting both dysfunctions of the mesolimbic dopamine pathway via direct activation of brain pathways.

강사소개

Chae Ha Yang Research Professor, Department of Physiology College of Korean Medicine Research Center for Herbal Convergence on Liver Disease Daegu Haany University Bachelor of Science in Pharmacy Seoul National University, Feb 1979 Master of Science in Pharmacology Seoul National University, Feb 1981 Doctor of Philosophy in Pharmacology Department of Pharmacology Catholic University of Daegu, September 1993 Professor, Department of Physiology, Daegu Haany University, Korea 1985-2019 Visiting Professor, Department of Neurology, Thomas Jefferson University, USA 1996-1997 My area of research involves investigating the neurobiological mechanisms of drug addiction. Currently, the main topic of research in my lab focuses on neural mechanisms underlying the effectiveness of acupuncture in the treatment of drug addiction. These studies involve a highly integrative and unique approach to identify the neural systems that mediate roles of acupuncture in suppressing drug reinforcement, craving and relapse to drug seeking with relatively complex rodent models of intravenous drug self-administration.
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