Objective: The aim of this study is to analyze the impact of acupuncture on severe short-term and long-term treatment complications and the overall 5-year survival of BC patients. Acupuncture is used for managing pain, nausea, and hot flashes in breast cancer (BC) patients. However, the effectiveness and risk of acupuncture on breast cancer patients’ anticancer treatment-related symptoms remain controversial. Methods: A nationwide database from Korean National Health Insurance Service database was used to identify newly diagnosed BC patients from 2011 to 2013 with records of mastectomy or lumpectomy. Using propensity score, patients who received acupuncture and those who did not were matched (propensity score matching). Survival analyses using Kaplan Meier curve and multivariable Cox proportional hazards ratio model were conducted to investigate the effect of acupuncture during post-operative period of three to six months after surgery on the risk of BCRL, and the effect of tramadol and duloxetine consumption after diagnosis of chemotherapy-induced peripheral neuropathy.