Objectives: This study aimed to develop head meridian activity measuring device, an EEG system tailored for measuring head meridian activity using a montage from traditional Korean medicine (TKM). The device included a 32-channel wireless EEG cap with a TKM diagnostic analysis program, a EEG transmitter, and an independent receiver with operating system, for the purpose of creation of TKM-based diagnostic analysis software. Methods: A wireless EEG system was developed, comprising the EEG cap with a montage reflecting head meridian distribution based on TKM theory, a transmitter, a receiver unit, and a software for non-Windows environments. A clinical study for collecting normative data for EEG from head meridian montage cap was also performed. Results: The new EEG system from head meridian montage demonstrated the feasibility of measuring head meridian activity. A 32-channel EEG cap was designed based on TKM principles, and components of the device was successfully developed. The TKM diagnostic analysis software included real-time data processing, visualization of waveforms, and storage. 200 samples retrieved from head meridian activity measuring device were collected. Conclusion: This study developed head meridian activity measuring device, an EEG system tailored for head meridian activity measurement in alignment with TKM principles. The components of the system, including the EEG cap, transmitter, and software, were designed and integrated based on TKM knowledge. The results suggest that the head meridian activity measuring device has potential for advancing TKM diagnostic capabilities and enhancing traditional medicine's role in brain-related disorder assessment and treatment.