Objectives: The objectives of this study were to develop clinical practice guidelines (CPGs) for Korean medicine (KM) on Dementia using the adaptation methodology, and to evaluate the feasibility and efficiency of this approach. Methods: We followed the adaptation methodology published by NECA, which consists of three phases: planning, adaptation, and finalization. We selected Dementia as the topic of interest based on the priority criteria and searched for relevant studies from domestic and international sources. We assessed the quality, currency, content, applicability, and acceptability of the retrieved CPGs using standardized tools. We selected the most suitable CPGs for adaptation and modified the recommendations according to the KM context and evidence. We determined the level of evidence and the grade of recommendation for each modified recommendation. We conducted external review and endorsement processes to ensure the validity and reliability of the developed CPGs. Results: We developed CPGs for KM on Dementia using the adaptation methodology. The CPGs provide comprehensive and practical guidance for KM practitioners and patients on the diagnosis, treatment, and prevention of Dementia. The CPGs also reflect the characteristics and needs of the KM clinical setting in Korea. The adaptation methodology was found to be a useful approach for developing CPGs for KM in a timely and efficient manner. Conclusions: The adaptation methodology can be applied to develop CPGs for KM on various topics. The developed CPGs for KM on Dementia can help improve the quality and consistency of KM practice and enhance patient outcomes.